Advil drug Uses, Dosage, Side Effects, Precautions & Warnings

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what is advil and is advil ibuprofen ?

Generic drug of the therapeutic class: Analgesics
active principles: Ibuprofen

This medicine contains a nonsteroidal anti-inflammatory drug: ibuprofen. It is indicated, in the adult and the child of more than 20 kg (is approximately 6 years), in the short treatment of the fever and / or pains such as headaches, flu-like states, dental pains, aches and painful periods.

use of advil tablet and indication

This medicine contains a nonsteroidal anti-inflammatory drug: ibuprofen.

It is indicated, in the adult and the child of more than 20 kg (approximately 6 years), in the short treatment of the fever and / or pains such as:

• headache,
• influenza States,
• dental pains,
• aches,
• painful periods.

Advil Dosage

The occurrence of side effects can be minimized by using the lowest possible dose for the shortest duration of treatment required to relieve symptoms (see Warnings and Precautions section ).

ADAPTED TO THE ADULT AND TO THE CHILD FROM 20 KG (about 6 years).

Painful and / or febrile conditions

advil dose for child

• In children, the usual dose is 20 to 30 mg / kg / day in 3 doses per day (without exceeding 30 mg / kg / day).
• In children from 20 to 30 kg (approximately 6 to 11 years): 1 tablet (200 mg), to be renewed if necessary after 6 hours. In all cases, do not exceed 3 tablets per day (600 mg).

advil dosage for adults

• In adults and children over 30 kg (approximately 11-12 years): 1 to 2 tablets (200 mg to 400 mg), to be renewed if necessary after 6 hours.
• In all cases, do not exceed 6 tablets per day (1200 mg).
• Elderly : As age does not affect the kinetics of ibuprofen, the dosage should not need to be changed according to this parameter. However precautions must be taken (see section Warnings and precautions for use ).

Frequency of administration

Systematic catches prevent pain or fever oscillations.

They should be spaced at least 6 hours.

Duration of the treatment

If the pain persists for more than five days or if it worsens, or if the fever persists for more than three days or if a new disorder occurs, the patient is advised to seek medical advice.

how does advil work

Pharmacotherapeutic group: Other analgesic and antipyretic. ATC Code: N02B.

Ibuprofen is a nonsteroidal anti-inflammatory drug belonging to the group of propionics derived from aryl carboxylic acid. It has the following properties:

1. Analgesic property,
2. Antipyretic property,
3.  Anti-inflammatory property,

Short-term inhibition property of platelet functions.

All of these properties are related to an inhibition of prostaglandin synthesis.

what are the advil side effects?

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Medications such as ADVIL 200mg, coated tablet may increase the risk of heart attack (myocardial infarction), chest pain, or stroke.

May occur allergic reactions:

1. · Cutaneous: rash on the skin (rash, “maculopapular rash”, “erythema multiforme”, “purpura”), itching (“pruritus”), edema, aggravation of chronic urticaria, facial
2. · Respiratory, asthma-like, breathing difficulty (“bronchospasm”), wheezing or difficulty breathing (“dyspnea”)
3. · Generalized: abrupt swelling of the face and neck with difficulty breathing (Quincke’s edema), anaphylactic reaction, hypersensitivity reaction.

In rare cases, bleeding, gastrointestinal perforation or digestive ulcer may occur (abdominal pain, upper abdominal pain, mouth discharge (“hematemesis”) or stool, stool stool black (“melaena”)), exacerbation of inflammation of the intestine (“colitis”) or Crohn’s disease (see section “Take special precautions with ADVIL 200mg, coated tablet”). These are all the more frequent as the dosage used is high.

It can exceptionally be observed headaches accompanied by nausea, vomiting and stiffness of the neck:

symptoms of meningitis.

1. Very rarely, bullous skin or mucous membrane manifestations can occur (burning sensation accompanied by redness with bubbles, blisters, ulcerations (“Lyell Syndrome” and “Stevens-Johnson Syndrome”).
2. Exceptionally, serious skin infections have been observed in case of chicken pox.
3. In all these cases, you should immediately stop the treatment and tell your doctor .

During treatment, it is possible that:

1. · Digestive disorders: upset stomach, vomiting, nausea, diarrhea, constipation, flatulence, difficult digestion (“dyspepsis”), abdominal distension, gastritis,
2. · Exceptionally, dizziness, dizziness, headache, rare disturbances of vision, significant decrease in urine, abnormal presence of blood in the urine (“hematuria”) and protein in the urine (“proteinuria”), renal failure, and other kidney diseases (“interstitial nephritis”, “nephrotic syndrome”, “papillary necrosis”).

In all these cases, you must inform your doctor .

Exceptionally, changes have been observed liver or blood count (abnormal drop in blood cell levels: white blood cells (“agranulocytosis”, “leukopenia”) or red blood cells (“anemia”, “aplastic anemia”, “Haemolytic anemia”, decreased hematocrit and hemoglobin) or platelets (“thrombocytopenia”) that can be serious.

Other very rare side effects:

1. ·nervousness, ringing of ears,
2. · Oral ulcers,
3. · Abnormally high blood pressure (“hypertension”),
4. · Heart failure,
5. · Liver problems: symptoms may include yellowing of the skin and whites of the eyes (“jaundice”), hepatitis,
6. · Peripheral edema, swelling.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of this month.

This medication should be stored at room temperature (10-25 ° C).

Do not dispose of any medicine in the trash or garbage. Ask your pharmacist to eliminate drugs you no longer use. These measures will help protect the environment.

Advil Interactions

Risk related to hyperkalemia

Certain drugs or therapeutic classes may promote the occurrence of hyperkalemia: potassium salts, potassium diuretics, angiotensin-converting enzyme inhibitors, angiotensin II antagonists, nonsteroidal anti-inflammatory drugs, heparins (low molecular weight or unfractionated), immunosuppressants such as ciclosporin or tacrolimus, trimethoprim.

The combination of these drugs increases the risk of hyperkalemia. This risk is particularly important with potassium-sparing diuretics, especially when they are combined with each other or with potassium salts, whereas the combination of an ACE inhibitor and an NSAID, for example, is safer as soon as possible. the moment that the recommended precautions are implemented.

To know the risks and stress levels specific to hyperkalemic drugs, it is necessary to refer to the interactions specific to each substance.

However, some substances, such as trimethoprim, are not the subject of specific interactions with regard to this risk. Nevertheless, they can act as contributing factors when combined with other drugs such as those mentioned above.

The simultaneous administration of ibuprofen with the following products requires a rigorous monitoring of the clinical and biological status of the patient:

Associations advised against (see section Warnings and precautions for use )

Other NSAIDs

Increased risk ulcerogenic and haemorrhagic digestive.

Acetylsalicylic acid at anti-inflammatory doses ( ³ 1 g per dose and / or ³ 3 g per day) or at analgesic or antipyretic doses ( ³ 500 mg per dose and / or <3 g per day)

Increased risk ulcerogenic and haemorrhagic digestive.

Oral anticoagulants

Increased bleeding risk of oral anticoagulant (aggression of gastric and duodenal mucosa by NSAIDs). NSAIDs may increase the effects of anticoagulants such as warfarin (see Warnings and Precautions section ).

If the association can not be avoided, close clinical and biological monitoring.

Unfractionated heparins, low molecular weight and related heparins (in curative doses and / or in the elderly)

Increased haemorrhagic risk (aggression of the gastroduodenal mucosa by NSAIDs).

If the association can not be avoided, close clinical supervision.

Lithium

Increased lithemia that can reach toxic values ​​(decreased renal excretion of lithium).

If the combination can not be avoided, closely monitor for lithium and adjust the dosage of lithium during the combination and after stopping the NSAID.

+        Methotrexate, used at doses greater than 20 mg / week

Increased hematological toxicity of methotrexate (decreased renal clearance of methotrexate by anti-inflammatory drugs).

+        Pemetrexed (patients with mild to moderate renal function, creatinine clearance between 45 ml / min and 80 ml / min)

Risk of increased toxicity of pemetrexed (decreased renal clearance by NSAIDs)

Associations requiring precautions for use

 Ciclosporin, tacrolimus

Risk of addition of nephrotoxic effects, especially in the elderly. Monitor renal function at the beginning of treatment with the NSAID.

+        Diuretics, ACE inhibitors, angiotensin II antagonists (AIIA)

Acute renal failure in the patient at risk (elderly and / or dehydrated) by reduction of glomerular filtration (inhibition of vasodilator prostaglandins by NSAIDs).

Moreover, reduction of the antihypertensive effect.

Hydrate the patient. Look at the kidney function at the start of the treatment.

+        Methotrexate, used at doses less than or equal to 20 mg / week

Increased hematological toxicity of methotrexate (decreased renal clearance of methotrexate by anti-inflammatory drugs).

Weekly control of the blood count during the first weeks of the association.

Increased monitoring for impaired (even mild) renal function, as well as in the elderly.

+        Pemetrexed (patients with normal kidney function)

Risk of increased toxicity of pemetrexed (decreased renal clearance by NSAIDs).

Biological monitoring of the renal function.

Associations to consider

+        Acetylsalicylic acid at anti-aggregating doses (50 mg to 375 mg daily in 1 or more doses)

Increased risk ulcerogenic and haemorrhagic digestive.

In addition, experimental data suggest that ibuprofen may inhibit the platelet anti-aggregating effect of a low dose of acetylsalicylic acid when taken concomitantly. However, the limitations of these ex-vivo data and the uncertainties as to their extrapolation in the clinic, do not allow to formally conclude with regard to the regular use of ibuprofen; moreover, for ibuprofen used occasionally, the occurrence of a clinically relevant effect appears unlikely.

Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs)

Increased risk of gastrointestinal bleeding. (see section Warnings and precautions for use )

Beta-blockers (except esmolol)

Reduction of antihypertensive effect (inhibition of vasodilator prostaglandins by NSAIDs and retention of water with NSAIDs pyrazole).

 Deferasirox

Increased risk ulcerogenic and haemorrhagic digestive.

+        Glucocorticosteroids (except hydrocortisone as replacement therapy)

Increased risk of ulceration and bleeding gastrointestinal tract (see Warnings and precautions for use )

+        Low molecular weight and related heparins and unfractionated heparins (at preventative doses)

Increased haemorrhagic risk

Advil Warnings and Precautions

Warnings

1. Concomitant use of ADVIL 200 mg coated tablet with other NSAIDs, including selective cyclooxygenase 2 (cox-2) inhibitors, should be avoided.
2. The occurrence of adverse effects may be minimized by the use of the lowest possible dose for the shortest duration of treatment required to relieve symptoms (see section 4.2) and gastrointestinal and cardiovascular effects. -Dessous).
3. Patients with asthma associated with chronic rhinitis, chronic sinusitis and / or nasal polyposis, have a risk of allergic manifestation when taking acetylsalicylic acid and / or nonsteroidal anti-inflammatory drugs higher than the rest of the population.
4. The administration of this specialty may lead to an asthma attack, particularly in some people allergic to acetylsalicylic acid or NSAIDs (see section Contraindications ).

Elderly

• Elderly patients have an increased risk of adverse effects to NSAIDs, particularly gastrointestinal bleeding and potentially fatal perforations.

Gastrointestinal effects

1. Gastrointestinal bleeding, ulceration or perforation, sometimes fatal, has been reported with all NSAIDs at any time during treatment, without necessarily warning signs or a history of adverse effects. gastrointestinal symptoms.
2. The risk of bleeding, ulceration or perforation of the gastrointestinal tract increases with the dose used in patients with a history of ulcer, particularly in the case of a complication such as haemorrhage or perforation (see Contraindications section). ) as well as in the elderly. In these patients, treatment should be started at the lowest dose possible. A mucosal protective treatment (eg misoprostol or proton pump inhibitor) should be considered for these patients, as for patients requiring treatment with low doses of acetylsalicylic acid or treated with other drugs that may increase gastrointestinal risk (see below and sectionInteractions with other drugs and other forms of interaction ).
3. Patients with a gastrointestinal history, especially elderly patients, should report any unusual abdominal symptoms (especially gastrointestinal bleeding), particularly at the beginning of treatment.
4. Special attention should be paid to patients receiving associated therapies that may increase the risk of ulceration or bleeding, such as oral corticosteroids, oral anticoagulants such as warfarin, selective reuptake inhibitors, and Serotonin (SSRI) and antiplatelet agents such as acetylsalicylic acid (see section 4.5 ).
5. If bleeding or ulceration occurs in a patient receiving ADVIL 200 mg, coated tablet, treatment should be discontinued.
6. NSAIDs should be administered with caution and under close supervision in patients with a history of gastrointestinal disease (ulcerative colitis, Crohn’s disease), because of a risk of aggravation of the pathology .

Cardiovascular and cerebrovascular effects

1. Adequate monitoring and recommendations are required in patients with a history of hypertension and / or mild to moderate heart failure, with cases of fluid retention and edema associated with NSAID therapy.
2. Clinical studies and epidemiological data suggest that the use of ibuprofen, especially when used at high doses (2400 mg per day) over a long course of treatment, may be associated with a slight increase in the risk of arterial thrombotic event (eg, myocardial infarction or stroke) (see Warnings and Precautions ) section. However, epidemiological data do not suggest that low doses of ibuprofen (£ 1200 mg daily) are associated with an increased risk of myocardial infarction.
3. Patients with uncontrolled hypertension, congestive heart failure, ischemic heart disease, peripheral arterial disease, and / or history of stroke (including transient ischemic attack) should be treated with ibuprofen only after a careful examination.
4. Similar attention should be paid to initiating long-term treatment in patients with risk factors for cardiovascular disease (such as hypertension, hyperlipidemia, diabetes or smoking).

Skin effects

1. Serious skin reactions, some of which are fatal, including exfoliative dermatitis, Stevens-Johnson syndromes, and Lyell syndromes have been reported very rarely in NSAID therapy (see section 4.8 ).
2. The incidence of these adverse effects appears to be greater at the beginning of treatment, the delay of onset being, in the majority of cases, during the first month of treatment. ADVIL 200 mg, coated tablet should be discontinued at the onset of rash, mucosal lesions or other signs of hypersensitivity.
3. Varicella can exceptionally cause serious skin and soft tissue infections. To date, the role promoting NSAIDs in worsening these infections can not be ruled out. It is therefore prudent to avoid the use of ADVIL 200 mg, coated tablet in case of chicken pox.

Functional renal insufficiency

NSAIDs, by inhibiting the vasodilator action of renal prostaglandins, are likely to cause functional renal failure by decreasing glomerular filtration. This side effect is dose dependent.

At the beginning of treatment or after dose increase, monitoring of diuresis and renal function is recommended in patients with the following risk factors:

· Elderly subjects,

1. · Associated drugs such as: ACE inhibitors, sartans, diuretics (see section Interactions with other medicinal products and other forms of interaction ),
2. · Hypovolemia, whatever the cause,
3. · heart failure,
4. · Chronic renal failure,
5. · nephrotic syndrome,
6. · Lupus nephropathy,
7. · Decompensated hepatic cirrhosis.

Hydro-Sodium Retention:

Hydro-Sodium retention with possibility of edema, hypertension or hypertension, worsening of heart failure. Clinical monitoring is necessary from the beginning of treatment in case of hypertension or heart failure. A decrease in the effect of antihypertensives is possible (see section Interactions with other medicinal products and other forms of interaction ).

Hyperkalemia:

1. Hyperkalemia favored by diabetes or concomitant treatment with hyperkalemic drugs (see section Interactions with other medicinal products and other forms of interaction ).
2. Regular monitoring of serum potassium should be performed under these circumstances.
3. This medication should be avoided if treated with another nonsteroidal anti-inflammatory drug, oral anticoagulant, lithium, analgesic, antipyretic, or anti-inflammatory acetylsalicylic acid with methotrexate. doses greater than 20 mg per week, with low molecular weight and related heparins and unfractionated heparins (at curative doses and / or in the elderly), with pemetrexed, in patients with low to moderate renal function (see section Interactions with other medicines and other forms of interaction ).

Special precautions for use

1. Ibuprofen, like any drug that inhibits the synthesis of cyclooxygenases and prostaglandins, can impair fertility. Its use is not recommended for women who want to conceive a child.
2. In case of visual disturbances occurring during treatment, a complete ophthalmological examination must be performed.
3. During prolonged treatments, it is recommended to check the blood count, liver function and kidney function.
4. This medicine contains sucrose. It is not recommended for use in patients with fructose intolerance, glucose-galactose malabsorption or sucrase / isomaltase deficiency.

Drive and use machines

Prevent patients from the possibility of vertigo and visual disturbances.

Advil and PREGNANCY / BREAST FEEDING / FERTILITY

advil and pregnancy

Malformative aspect ( ^1st quarter):

1. Studies in animals have not shown any teratogenic effect.
2. In the absence of teratogenic effect in animals, a malformative effect in the human species is not expected. Indeed, to date, the substances responsible for malformations in the human species have proved teratogenic in animals in well conducted studies on two species.
3. In humans, no effect malformation particular, related to administration during the 1 ^st  trimester, were reported. However, further epidemiological studies are needed to confirm the absence of risk.

Fetotoxic and neonatal aspect (2 ^e and 3 ^e quarters):

This is a class toxicity for all prostaglandin synthesis inhibitors.

The administration for the 2 ^e and 3 ^e quarter exposed to:

• renal functional impairment:
  • in utero can be observed as early as 12 weeks of amenorrhea (initiation of fetal diuresis): oligoamnios (most often reversible at the end of treatment), even anamnios especially during prolonged exposure;
  • at birth, renal failure (reversible or not) may persist, especially in case of late and prolonged exposure (with a risk of delayed severe hyperkalemia);
• a risk of cardiopulmonary involvement: partial or complete constriction in utero of the arterial canal. Cannulation of the ductus arteriosus can occur after 5 months of age and can lead to fetal or neonatal right heart failure or even fetal death in utero . This risk is even more important that the catch is close to the term (less reversibility). This effect exists even for a punctual catch;
• a risk of increased bleeding time for the mother and the child.

Consequently :

• Up to 12 weeks of amenorrhea: Advil 200 mg or Advilcaps 200 mg should be used only if necessary.
• Between 12 and 24 weeks of amenorrhea (between the beginning of fetal diuresis and 5 months): a brief intake should only be prescribed if necessary. Prolonged intake is strongly discouraged.
• Beyond 24 weeks of amenorrhea (5 months): any taking, even punctual, is contraindicated ( see Contraindications ). An inadvertent intake beyond 24 weeks of amenorrhea (5 months) justifies cardiac and renal, fetal and / or neonatal monitoring according to the term of exposure. The duration of this monitoring will be adapted to the elimination half-life of the molecule.

advil and Breastfeeding

NSAIDs passing into breast milk, as a precaution, should be avoided in women who are breastfeeding.

In case of accidental overdose or intoxication, STOP THE TREATMENT AND CONSULT A DOCTOR QUICKLY.

What is  Forms and Composition Advil?

FORMS and PRESENTATIONS

Advil:

• 200 mg coated tablet:  Boxes of 20 and 30, blister packs of 10. Advilcaps:Soft capsule 200 mg (light green, with 200 printed in white ink):   Box of 16, blister packs.

COMPOSITION

Advil:

	p cp
Ibuprofen	200mg

Excipients: maize starch, pregelatinized starch, anhydrous colloidal silica, stearic acid, sucrose, oxidized potato starch (Perfectamyl gel 45), povidone, polysorbate 80, macrogol 6000, titanium dioxide (E 171), calcium carbonate, talc, carnauba wax, red iron oxide (E 172). Black printing ink: Opacode S-1-17823 (Shellac, Black Iron Oxide [E172], N-Butylalcohol, Purified Water, Propylene Glycol, Isopropyl Alcohol, Ammonium Hydroxide).

Excipient with known effect: sucrose.

Advilcaps:

	p capsule
Ibuprofen	200mg

Excipients: macrogol 600, potassium hydroxide (50% solution). Capsule shell :partially dehydrated liquid sorbitol, gelatin, purified water, patent blue V (E 131), quinoline yellow (E 104). Ink for printing: White opacode NSP-78-18022: alcohol SDA 35A, propylene glycol, titanium dioxide (E 171), polyvinyl acetophthalate, purified water, isopropyl alcohol, macrogol 400, 28% ammonium hydroxide.

Excipient with known effect: Sorbitol (E 420).

NOT’s

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general information:

• Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

• General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

• For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

• It treats possible side effects and drug interactions that require attention and its effect on continuous use.
• The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

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